pI: 7.5534 |
Length (AA): 753 |
MW (Da): 85345 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
69 | 226 | 3f0w (A) | 57 | 200 | 16.00 | 0 | 0.46 | 0.304627 | -0.66 |
86 | 222 | 2cy5 (A) | 30 | 159 | 31.00 | 0.00000008 | 1 | 0.613039 | -1.19 |
508 | 554 | 4o9b (A) | 271 | 314 | 30.00 | 0 | 0.02 | 0.414217 | -1.65 |
509 | 555 | 5jxc (A) | 1203 | 1254 | 43.00 | 0.94 | 0.01 | 0.510417 | -1.23 |
618 | 683 | 1wxb (A) | 6 | 67 | 37.00 | 0 | 1 | 0.529449 | -0.84 |
620 | 682 | 1neg (A) | 7 | 69 | 32.00 | 0.0055 | 1 | 0.579665 | -1.12 |
622 | 683 | 1wxt (A) | 10 | 67 | 48.00 | 0 | 1 | 0.625137 | -0.79 |
629 | 674 | 1jqq (A) | 24 | 76 | 26.00 | 0.85 | 0.71 | 0.255089 | -0.19 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131937)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_37645 | epidermal growth factor receptor pathway substrate 8 splice variant B |
Caenorhabditis elegans | CELE_Y57G11C.24 | Protein EPS-8, isoform G |
Drosophila melanogaster | Dmel_CG8907 | CG8907 gene product from transcript CG8907-RA |
Drosophila melanogaster | Dmel_CG4276 | arouser |
Echinococcus granulosus | EgrG_000099700 | epidermal growth factor receptor kinase |
Echinococcus multilocularis | EmuJ_000099700 | epidermal growth factor receptor kinase |
Homo sapiens | ENSG00000151491 | epidermal growth factor receptor pathway substrate 8 |
Homo sapiens | ENSG00000177106 | EPS8-like 2 |
Loa Loa (eye worm) | LOAG_04380 | hypothetical protein |
Mus musculus | ENSMUSG00000015766 | epidermal growth factor receptor pathway substrate 8 |
Mus musculus | ENSMUSG00000025504 | EPS8-like 2 |
Schistosoma japonicum | Sjp_0207470 | Epidermal growth factor receptor kinase substrate 8-like protein 1, putative |
Schistosoma mansoni | Smp_035260.3 | epidermal growth factor receptor kinase substrate eps8-related protein |
Schmidtea mediterranea | mk4.011429.00 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y57G11C.24 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y57G11C.24 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y57G11C.24 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y57G11C.24 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y57G11C.24 | Caenorhabditis elegans | sterile | wormbase |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.